MedCubs

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Updated: May 18, 2026 at 6:43 AM

MedCubs

Hello doctors, This Channel is specially curated for NEXT, INICET, USMLE, FMGE, PLAB & other Competitive exam preparation. Any queries or any promotions contact @SayanMisra_10

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MedCubs

May 19, 2026, 03:46 AM

Answer164.

• Propylthiouracil is antithyroid drug of choice in pregnancy. It also has the advantage of being excreted to a lesser extent than carbimazole in breast milk.

PREGNANCY: THYROID PROBLEMS
• In pregnancy there is an increase in the levels of thyroxine binding globulin (TBG).
• This causes an increase in the levels of total thyroxine but does not affect the free thyroxine level

Thyrotoxicosis:
• Untreated thyrotoxicosis increases the risk of fetal loss, maternal heart failure and premature labour
• Graves' disease is the most common cause of thyrotoxicosis in pregnancy. It is also recognised that activation of the TSH receptor by HCG may also occur - often termed transient gestational hyperthyroidism. HCG levels will fall in second and third trimester.

Hypothyroidism
Key points
• Thyroxine is safe during pregnancy
• Serum thyroid stimulating hormone measured in each trimester and 6-8 weeks post-partum
• Some women require an increased dose of thyroxine during pregnancy
• Breast feeding is safe whilst on thyroxine

Ans. D. Propylthiouracil

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MedCubs

May 19, 2026, 03:46 AM

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DAPTOMYCIN

Follow us for more such Contents daily😇😎

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May 19, 2026, 03:46 AM

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May 19, 2026, 03:46 AM

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MedCubs

May 19, 2026, 03:46 AM

Answer163.

• Recent advancement C 11 Pittsburg compound b is used in early diagnosis of Alzheimer’s even before the symptoms will appear as it goes and bind to amyloid plaque.
• 18-FDG is used for evaluation of solitary pulmonary nodule ,bone METs NaF PET is used for evaluating bone METs.
DOPA PET is useful in detecting extra abdominal pheochromocytoma

Ans: C. C11 Pittsburg compound b PET

#MedCubs #Explanation

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MedCubs

May 19, 2026, 03:46 AM

Q163. A 60 year old male has become progressively unable to live independently in recent 4 yrs and requires assistance for his daily activities On Examination: No motor and sensory deficits. Which Radio isotope PET scan be done to see amyloid plaque?

A. 18-FDG PET
B. NaF PET
C. C11 Pittsburg compound b PET
D. DOPA PET

#MedCubs #ClinicalCases

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MedCubs

May 19, 2026, 03:46 AM

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MedCubs

May 19, 2026, 03:46 AM

Q164. A 29-year-old female who is 14 weeks into her first pregnancy is investigated for excessive sweating and tremor. Blood tests reveal the following: TSH < 0.05 mu/l T4 188 nmol/l What is the most appropriate management?

A. Immediate surgery
B. Carbimazole
C. Surgery at start of third trimester
D. Propylthiouracil

#MedCubs #ClinicalCases

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MedCubs

May 19, 2026, 03:46 AM

Answer 161.

Chi-Square Test
• Chi-Square test tells us about whether we can reject null hypothesis
• We have significant evidence to prove alternate hypothesis, i.e. significance of association. .

Explanation for incorrect options:
• Option A: Paired T test: Used to compare mean value of same population before and after intervention.

• Option B: Used to see the difference between two man of two independent groups is statistically significant or not. Eg: two see effect of two medications

Ans. C. Chi-Square Test

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MedCubs

May 19, 2026, 03:46 AM

Answer162.

1. Usually the symptoms of acid-peptic disease are caused by acid.
2. In gastric ulcer, generally acid secretion is normal or low, while deficient mucosal defence (mostly impaired mucus and bicarbonate secretion) plays a greater role.
3. Antacids are basic substances which neutralize gastric acid and raise pH of gastric contents
4. Although antacids seem to have no ability to accelerate ulcer healing, they act almost instantaneously to neutralize acid (provided adequate dosages are given), thereby relieving pain and other discomforts that are due to the acid in a matter of a minute or so.
5. All the other drugs can, to varying degrees, suppress gastric acid secretion and ultimately get the patient to a “ no acid, no pain" state.
6. However, it takes some time (variable, but clearly longer than it takes for an antacid to work) for other medications to be absorbed and reach blood levels sufficient to suppress acid production and then reduce symptoms.

Ans. A. Antacids

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