Are you interested in hematology this is deep thinking case study with aberrant immunophenotyping. A 38-year-old young woman. We had several of her materials in the department: l/a, bone marrow sample, blood, aspirate. She was already admitted seriously, with massive lymphadenopathy. And the first one we looked at was her lymph node, where, against the background of follicular lymphoma remnants, we found proliferation of large cells with CD19, CD10, bcl-2, bcl-6, and c-myc expression with high proliferative activity (Ki-67-90%). But the expression of CD5, CD3, CD20, CD23, CD30, CD79a, TdT, CD34, LMO2, MPO was absent in them. I was particularly surprised by the absence of the linear marker CD79a, and CD20 was negative in IHC. We decided to wait for the results of the IFT, and I already had this patient's blood in the work. Let's take a look at it. There are two populations here: blue (small cells) and large (red).
According to IFT, CD79a expression was also absent in large cells, but CD20 was quite bright.
